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SLC12A8 has been proposed as an NMN transporter into the cell 70 , but this is still debated 71,72

A later review framed the molecule honestly as a still unresolved riddle, conceding that decades of study had not pinned down a mechanism or a confirmed physiological role (PMID 16539679)

The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

Deficiency SAMe levels tend to decline as people age

He characterized Canadays criticism as personal and pointed to Canadays stated veganism and opposition to hunting as part of the underlying disagreement